Natural micropolymorphism in human leukocyte antigens provides a basis for genetic control of antigen recognition
نویسندگان
چکیده
منابع مشابه
Natural micropolymorphism in human leukocyte antigens provides a basis for genetic control of antigen recognition
Human leukocyte antigen (HLA) gene polymorphism plays a critical role in protective immunity, disease susceptibility, autoimmunity, and drug hypersensitivity, yet the basis of how HLA polymorphism influences T cell receptor (TCR) recognition is unclear. We examined how a natural micropolymorphism in HLA-B44, an important and large HLA allelic family, affected antigen recognition. T cell-mediate...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 2009
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.20082136